In particle beam therapy cancer local treatment, current beam delivery strategies aimed at minimizing uncertainties from organ motion are based on respiratory gating, re-scanning or tracking.
Information on the motion can be assessed prior to the treatment, e.g., on the basis of time-resolved fourdimensional (4D) Computed-Tomography (CT) data, and monitored during treatment, typically by means of an external surrogate. Dose deposition patterns are investigated through in-beam/in-room PET imaging. The aim of the project ENVISION (European Novel Imaging Systems for Ion therapy) is to assess the feasibility and potential of in-vivo dosimetric imaging systems for the quality assurance of motion-compensated dose delivery and to optimize performance via the investigation and selection of the most accurate and reliable 4D motion monitoring systems which are integrated into the in-vivo dosimetric data acquisition and processing techniques.