On November 6th and 7th 2019, the kick off meeting of SINERGIA (Advanced technologieS for drug dIscovery and precisioN mEdicine: in vitRo modellinG human physiology and diseAse) has taken place at Politecnico di Milano. SINERGIA is a project funded by the European Union in the framework of the H2020 Marie Skłodowska Curie Actions – Innovative Training Networks. SINERGIA aims at improving the dialogue among the main stakeholders in the drug discovery field, and at developing advanced models of human physiology and diseases, to be ultimately introduced in the preclinical stages of the drug discovery pipeline. SINERGIA’s research programme addresses three investigational areas of the drug development process – namely drug benefit, drug safety and precision medicine – with the aim of bringing advanced models built on innovative Technologies from bench to the pharmaceutical market. SINERGIA provides career development and training opportunities for 15 researchers who are in the first 4 years of their research careers (Early-Stage Researchers, ESRs). For further information: https://www.sinergia2020.polimi.it/