This is the extraordinary result obtained in the MiMic Lab (Microfluidic and Biomimetic Microsystems) of the Department of Electronics, Information and Bioengineering of Politecnico di Milano by Marco Rasponi, research coordinator together with Andrea Barbero of the University Hospital of Basel. A sophisticated coin-sized chip in which it is possible to cultivate cartilage and subsequently subject it to mechanical stimulus in order to provoke the effects of osteoarthrosis (OA): inflammation, hypertrophy and progressive degradation processes. In the cartilage "on a chip", therefore, an ideal environment is created in which to test the efficacy and the action of drugs, shortening experimental time and costs and decreasing the need for animal testing. The research will continue, with the coordination by Politecnico di Milano, towards the modeling of the entire articulation on a chip, thanks to a Cariplo Foundation project funded in response to the call "Biomedical Research on 2018 aging-related diseases". The title of the project is "uKNEEque: a 3D microfluidic osteochondral model to investigate mechanisms triggering age-related joint pathologies and therapeutic effects of bioactive factors produced by nasal chondrocytes". Politecnico di Milano is the Research Coordinator. The study was published in Nature Biomedical Engineering (https://www.nature.com/articles/s41551-019-0406-3).