Computational and Experimental Methods to Predict Thrombosis and Thromboembolization
Prof. Keefe B. Manning
Pennsylvania State University
University Park, PA, USA
DEIB - Alario Room (Bld. 21)
June 14th, 2023
3.30 pm
Contacts:
Monica Soncini
Research Line:
Biological and Biomechanical Engineering
Pennsylvania State University
University Park, PA, USA
DEIB - Alario Room (Bld. 21)
June 14th, 2023
3.30 pm
Contacts:
Monica Soncini
Research Line:
Biological and Biomechanical Engineering
Abstract
On June 14th, 2023 at 3.30 pm Keefe B. Manning, Professor of Biomedical Engineering and Surgery Artificial Heart and Cardiovascular Fluid Dynamics Labs at The Pennsylvania State University Park USA, will hold a seminar on "Computational and Experimental Methods to Predict Thrombosis and Thromboembolization" in DEIB Alario Room (Building 21).
Thrombosis remains a significant clinical issue manifesting in heart attacks and strokes. However, the challenges extend to the success of cardiovascular devices. Given the complex process associated with thrombosis, developing accurate computational models is challenging particularly validating the models that encompasses a range of flow and surface interactions and occurs at different temporal and spatial scales. Leveraging canonical experiments that acquire a breadth of data will be crucial to validate any computational model. Furthermore, there are different mathematical approaches that may be used to model thrombosis with some ideally suited for predicting embolization. This presentation will cover the development and experimental validation of the computational models and ongoing methods that add more complexity and accuracy to the models. Ultimately, the goal of the models is to be sensitive to different material surfaces and respond to low and high shear environments to predict thrombus formation and potential embolization.
Thrombosis remains a significant clinical issue manifesting in heart attacks and strokes. However, the challenges extend to the success of cardiovascular devices. Given the complex process associated with thrombosis, developing accurate computational models is challenging particularly validating the models that encompasses a range of flow and surface interactions and occurs at different temporal and spatial scales. Leveraging canonical experiments that acquire a breadth of data will be crucial to validate any computational model. Furthermore, there are different mathematical approaches that may be used to model thrombosis with some ideally suited for predicting embolization. This presentation will cover the development and experimental validation of the computational models and ongoing methods that add more complexity and accuracy to the models. Ultimately, the goal of the models is to be sensitive to different material surfaces and respond to low and high shear environments to predict thrombus formation and potential embolization.
Short Bio
Dr. Keefe B. Manning is a Professor of Biomedical Engineering and Professor of Surgery (courtesy) at The Pennsylvania State University. He completed his B.S. in Bioengineering in 1995 and his M.S. in Bioengineering in 1997 at Texas A&M University. Subsequently,
he completed his Ph.D. in Biomedical Engineering in 2001 at Virginia Commonwealth University studying flow of a centrifugal blood pump. He spent 2001-2004 as a post-doctoral scholar With John Tarbell, Ph.D. at Penn State studying the fluid mechanics of prosthetic heart valves before starting his faculty appointment in 2004 at Penn State. Dr. Manning and his research team study flow associated with cardiovascular devices (e.g., blood pumps, valves, IVC filters, cannulae, thrombectomy devices, and ECMO). His group also studies how clotting occurs with these devices and is developing computational models to predict clot formation and embolization. His group is also investigating acute ischemic stroke and venous thromboembolism. His research has been sponsored by the National Institutes of Health, National Science Foundation, American Heart Association, U.S. Food and Drug Administration, U.S. Department of Defense, Grace Woodward Foundation, and industry.
He holds fellow status in the American Institute for Medical and Biological Engineering and the American Society of Mechanical Engineers.
The event will be held online by Webex.
he completed his Ph.D. in Biomedical Engineering in 2001 at Virginia Commonwealth University studying flow of a centrifugal blood pump. He spent 2001-2004 as a post-doctoral scholar With John Tarbell, Ph.D. at Penn State studying the fluid mechanics of prosthetic heart valves before starting his faculty appointment in 2004 at Penn State. Dr. Manning and his research team study flow associated with cardiovascular devices (e.g., blood pumps, valves, IVC filters, cannulae, thrombectomy devices, and ECMO). His group also studies how clotting occurs with these devices and is developing computational models to predict clot formation and embolization. His group is also investigating acute ischemic stroke and venous thromboembolism. His research has been sponsored by the National Institutes of Health, National Science Foundation, American Heart Association, U.S. Food and Drug Administration, U.S. Department of Defense, Grace Woodward Foundation, and industry.
He holds fellow status in the American Institute for Medical and Biological Engineering and the American Society of Mechanical Engineers.
The event will be held online by Webex.
