Speakers: Prof. Dr. med. Jochen Klucken, Dr. Francesca Terranova
(Digital Medicine, University of Luxembourg)
20 Ottobre 2026 | 15:00 - 17:00
DEIB, Sala Seminari “A. Alario” (Ed. 21)
Contatti: Proff. Riccardo Barbieri, Monica Soncini
Sommario
In the framework of the of Biomedical Engineering PhD Course on October 20th, 2026 starting from 3:00 pm, will be held two seminars in DEIB “Alessandra Alario” Seminar Room (Building 21)."Clinical utility of digital diagnostic" - Prof. Dr. med. Jochen Klucken
Wearable sensors and patient-reported outcome measures are increasingly providing the opportunity to support research and care. The Digital Medicine Group is addressing the integration of health technology innovations including sensor-based objective assessments, as well as subjective patient-centered self-evaluation into healthcare procedures. The understanding of this "clinical utility" is crucial for the transfer of innovative health technologies into reimbursed and adopted digital medical devices. The presentation will address this translational gap: from bits to bedside, and also introduce the current work of the Digital Medicine Group in Luxembourg.
"Tracking Orthostatic Hypotension in Parkinson's Disease with Sensor-Based Monitoring" - Dr. Francesca Terranova
Orthostatic hypotension, a sharp drop in blood pressure on standing, affects 30–50% of people with Parkinson's disease, yet it is often missed because conventional assessment relies on isolated, in-clinic blood-pressure readings. This talk presents Pulse Arrival Time (PAT), a beat-to-beat measure derived from ECG and PPG, as a digital diagnostic marker of the orthostatic cardiovascular response. In a study of 59 participants performing a Schellong (active-standing) test, the dynamics of PAT distinguished Parkinson's patients with orthostatic hypotension from those without, whereas heart rate did not differ between the groups. The talk discusses what PAT could offer as an early step toward sensor-based assessment of autonomic dysfunction, alongside standard clinical evaluation.
Biografia
Prof. Dr. med. Jochen Klucken is a neurologist, neuroscientist, and full professor and Chair of Digital Medicine at the University of Luxembourg and the Centre Hospitalier de Luxembourg. His research focuses on I) shaping and innovating personalized digital healthcare solutions, II) evaluating the medico-socio-economic benefit of new digital medical devices and services, and III) assessing the societal impact of AI driven health technologies on patients with Parkinson disease, their healthcare professionals, related researchers, regulators, and policy makers. This implementation research approach targets all healthcare stakeholder needs: patient empowerment, healthcare provider quality, payers’ efficiency, social transformation, and acceptance, as well as regulatory and policy changes. With a broad interdisciplinary experience on health technology development and deployment he also supports start-ups, public and private clinical research requirements for innovative healthcare technologies, business cases, and sustainable data-driven healthcare services.Francesca Terranova is a doctoral researcher in the Digital Medicine group at the University of Luxembourg, where she uses wearable devices to study Parkinson's disease, focusing on cardiovascular dysfunction, particularly orthostatic hypotension, and gait abnormalities. Her work combines wearable signals (ECG, PPG, IMU) with patient-reported outcomes to develop and validate biomarkers that capture autonomic and motor alterations continuously and outside the clinical setting. She studied at Politecnico di Milano, where she obtained her bachelor's and master's degrees in biomedical engineering.