Most relevant research achievements
Design of technological platforms and tools to study neural functions in physiological and pathological conditions:
Availability of a device for selective optical stimulation and reading of in vitro cells population electrical activity, equipped with optoelectronic biosensors for optical recordings of neuronal activity.
Availability of an instrumented environmental chamber for multi MEAs (Microelectrodes Arrays) technology for non-invasive and multi-site electrophysiology of neuronal networks.
Analysis of optical and/or electrical data obtained from neuronal populations:
Design and development of dedicated software for data analysis of the electrical activity of culture of cell populations.
Tools for analysis and characterization of biomolecules and biomimetic surfaces. Tools for molecular docking in ligand-receptor analyses. Molecular basis of protein misfunctions.
Microfluidic devices for cell-based applications:
Design and development of microfluidic platforms compatible with cell culture experiments, enabling for spatio-temporal control of chemical and physical factors. Development of microstructured substrates to study/direct cell behaviour. Techniques to microstructure cell-populated hydrogels as i) in vivo-like 3D cell culture models, and ii) functional units for layer-by-layer biofabrication. High-throughput devices for cell and molecular screening, drug discovery/delivery, cell transfection.
Advanced culture system for tissue engineering and regenerative medicine:
Advanced cell culture platform for cardiac and vascular tissue engineering, de/recellularisation of biological tissues, and perfusion systems for stem cells expansion/differentiation. Ex vivo organ culture for mimicking different physiopathological environments to assess molecular and cellular mechanisms involved in cardiovascular disease evolution. Design of bioreactor systems for the screening of molecular and cellular based therapeutic options.