On December 4th, 2017
at 12.00 pm, Colin Logie
will give a seminar on genomics in DEIB Seminar Room
- Transcription factor-mediated signalling to the genome often takes place through very distant interactions between transcription enhancers and gene promoters.
- Experimental evidence pertaining to the existence and dynamic behaviour of TADs in the face of changing RNA polymerase II transcription frequencies will be presented.
- I will show how recently reported TADs enable efficient unsupervised integration of disparate data sets such as transcription factor ChIP-seq, histone- modification ChIP-seq and RNA-seq NGS reads.
After obtaining a B.Sc. degree in genetics at Glasgow University in 1991 Colin Logie earned his Ph.D. at the EMBL in Heidelberg, Germany in 1995, for developing steroid-inducible site-specific DNA recombinase protein fusions. During his post-doctoral research period at UMASS (Worcester, MA-USA) he demonstrated transcription factor activation domain-dependent recruitment of SWI/SNF activity to in vitro-reconstituted polynucleosome arrays. In 1999 he joined the Molecular Biology department of the Nijmegen Radboud University in the Netherlands where he studied yeast and human SWI/SNF complexes and discovered the H3K56ac epigenetic mark. During the last 5 years his research focussed on innate immunity and the epigenetic programs that unfold upon primary human monocyte differentiation.