Elettronica > Bioelectronics and biophotonic interfaces between cells and artificial systems

Abstract del Progetto

The development of cell-based biosensors for pharmaceutical, environmental, toxicological, scientific and other applications has received growing interest in recent years.
The project aims at the development of improved tools for interfacing cells and chips along two distinct paths: microelectronics and integrated optics. The former will take advantage of the integration capabilities of modern microelectronics to develop a compact system integrating a high-resolution array and the processing circuitry, in order to build a truly portable, low-cost device that could be adopted in routine analysis. The latter targets the development of integrated photonic devices, from the caged neurotransmitters and from the voltage-sensitive dyes, in order to realize a neuro chemo-photonic communication between biological and artificial parts. These technologies allow the microscale stimulation input to meet with the net macroscale output.
The activity of DEI researchers will be:

  • Characterization of electrodes realized in standard CMOS technology and their impedance in contact with the electrolytes; evaluation of possible non-lithographic methods for improved electrical contact and cell positioning;
  • Design of integrated amplifiers for cell signal detection; extension to arrays of microelectrodes; possible integration of the A/D converter; realization and test of the integrated circuits;
  • Realization of the setup for in-vivo experiments for BMI; analysis of the correlation with movements; development of integrated circuits for compact BMI.

The WP objectives for the first year can be considered to be fully achieved, with also some advances in what was originally scheduled for the second year.

64-channel amplifier for neuronal signal readout

Risultati del progetto ed eventuali pubblicazioni scientifiche/brevetti

First-year activities involved the definition of the amplifier characteristics and the analysis of coating procedures for the electrodes on one hand, and the definition of the design parameters for a chip to be adopted in field stimulation.
List of Patents and publications:
R. Gusmeroli, A. Bonfanti, T. Borghi, A. S. Spinelli and G. Baranauskas, "A switched-capacitor neural preamplifier with an adjustable pass-band for fast recovery following stimulation", Proc. 28th Annual Int. Conf. IEEE EMBS, New York, NY: 652-655 (2006)

T. Borghi, G. Riccardo, F. Galbusera, D. Servello, C. Pacchetti, A. S. Spinelli, G. Baranauskas, "Neuronal firing rates are direction sensitive in human subthalamic nucleus", Society for Neuroscience Annual Meeting, Atlanta, GA (2006)

T. Borghi, R. Gusmeroli, A. S. Spinelli, G. Baranauskas, "A simple method for efficient spike detection in multiunit recordings", Journal of Neuroscience Methods 163, 176–180 (2007)

Submitted for publication
R. Gusmeroli, A. Bonfanti, T. Borghi, A. S. Spinelli and G. Baranauskas, "A tunable integrated neural amplifier with short deadtime after stimulation", submitted for publication in IEEE Transactions on Biomedical Engineering Letters

T. Borghi, A. Bonfanti, G. Zambra, R. Gusmeroli, A. L. Lacaita, A. S. Spinelli, and G. Baranauskas, "A compact multichannel system for acquisition and processing of neural signals", submitted for presentation at 29th Annual International Conf. of the IEEE EMBS.