VPH2 aims to develop a patient-specific computational modeling and simulation of the human heart to assist the cardiologist and the cardiac surgeon in defining the severity and extent of disease in patients with post-ischemic left ventricular dysfunction (LVD), with or without ischemic mitral regurgitation (IMR). Specific computational methods will allow for clinical decision making and planning the optimal treatment for left ventricle-valve repair. In particular, the virtual approach to the organ pathology starts from the definition of the topographic location of myocardial dysfunction by analysing the myocardial functional behaviour (MRI 3-4D), and from the visualisation of transvalvular fluxes (MRI phase contrast), and mitral valve function and anatomy.
The analysis of each of these parameters contributes to formulate the risk prediction, based on historic findings and comparison with virtual physiology, with a direct impact on prognostic stratification.