Development and validation of hybrid models for the implementation of patient specific hemodynamics analysis
Responsible:
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Start date: 2011-01-01
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Project abstract
The project is focused on the individuation and implementation of a method for patient specific hemodynamic analysis which allows the integration of in vivo anatomical and hemodynamic data - measured by MRI - with numerical simulations of computational fluid dynamics (CFD).
In particular, the work deals with the assimilation of unsteady three-dimensional blood velocity fields into the incompressible Navier-Stokes equations, in computational domains built from patient-specific anatomical images.
The research is aimed:
The final goal of the research will be to obtain accurate and reliable information useful to diagnostic/prognostic aims, regarding the interactions between hematic flow and vascular pathologies, like atherosclerosis.
In particular, the work deals with the assimilation of unsteady three-dimensional blood velocity fields into the incompressible Navier-Stokes equations, in computational domains built from patient-specific anatomical images.
The research is aimed:
- to improve the accuracy and reliability of the simulations results, which are used to predict physical variables of medical relevance, to design of new therapies and, more in general, in the decision making process of medical doctors,
- to validate the velocity fields acquired with MRI and to reduce noise and measurement errors by forcing the observations to obey to the physical laws of the system.
The final goal of the research will be to obtain accurate and reliable information useful to diagnostic/prognostic aims, regarding the interactions between hematic flow and vascular pathologies, like atherosclerosis.