SurgAid
Research Area:
Research Lines:
Research Lines:
PRIN (Relevant National Interest Projects)
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Start date: 2007-01-01
Length: 36 months
Project abstract
SurgAid: New methods for diagnosis and support in mitral valve surgery repair procedures based on the integration of finite element modelling and 4D echocardiographic advanced image processing.
The aim of the SurgAid project is to develop and apply new methods for diagnosis and support in mitral (MV) surgery repair procedures, based on the combined analysis and integration of finite element models (FEM) approach with the patient-specific quantification of 4D valvular anatomy by advanced image processing of echocardiographic images.
Several algorithms for tissue tracking were created to semi-automatically quantify the mitral valve annulus and papillary muscles motion during the heart cycle in each specific patient. This information was used as constraint to guide the evolution of the relevant patient-specific FEM MV model simulating valve closure during systole, from which novel information about leaflet strain distribution ahs been extracted and correlated with pathology.
The aim of the SurgAid project is to develop and apply new methods for diagnosis and support in mitral (MV) surgery repair procedures, based on the combined analysis and integration of finite element models (FEM) approach with the patient-specific quantification of 4D valvular anatomy by advanced image processing of echocardiographic images.
Several algorithms for tissue tracking were created to semi-automatically quantify the mitral valve annulus and papillary muscles motion during the heart cycle in each specific patient. This information was used as constraint to guide the evolution of the relevant patient-specific FEM MV model simulating valve closure during systole, from which novel information about leaflet strain distribution ahs been extracted and correlated with pathology.
Project results
- F. Maffessanti, P. Gripari, G. Tamborini, M. Muratori, L. Fusini, F. Alamanni, M. Zanobini, C. Fiorentini, EG. Caiani, M. Pepi: “Evaluation of Right Ventricular Systolic Function after Mitral Valve Repair: A Two-Dimensional Doppler, Speckle-Tracking, and Three-Dimensional Echocardiographic Study”, Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography, vol. 25, pp. 701-708, 2012.
- MA. Sciancalepore, F. Maffessanti, AR. Patel, M. Gomberg-Maitland, S. Chandra, BH. Freed, E. G. Caiani, RM. Lang, V. Mor-Avi: “Three-dimensional analysis of interventricular septal curvature from cardiac magnetic resonance images for the evaluation of patients with pulmonary hypertension”, The international journal of cardiovascular imaging, vol. 28, pp. 1073-1085, 2012.
- E. G. Caiani, L. Fusini, F. Veronesi, G. Tamborini, F. Maffessanti, P. Gripari, C. Corsi, M .Naliato, M. Zanobini, F. Alamanni, M. Pepi: “Quantification of Mitral Annulus Dynamic Morphology in Patients with Mitral Valve Prolapse undergoing Repair and Annuloplasty during a 6-months Follow-up”, European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology, vol. 12, pp. 375-383, 2011.
- L. Fusini, G. Tamborini, P. Gripari, F. Maffessanti, V. Mazzanti, M. Muratori, L. Salvi, E. Sisillo, E. G. Caiani, F. Alamanni, C. Fiorentini, M. Pepi: “Feasibility of Intraoperative Three-Dimensional Transesophageal Echocardiography in the Evaluation of Right Ventricular Volumes and Function in Patients Undergoing Cardiac Surgery”, Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography, vol. 24, n. 8, pp. 868-877, 2011.
- F. Maffessanti, NA. Marsan, G. Tamborini, L. Sugeng, EG. Caiani, P. Gripari, F. Alamanni, V. Jeevanandam, RM. Lang, M. Pepi: “Quantitative analysis of mitral valve apparatus in mitral valve prolapse before and after annuloplasty: a three-dimensional intraoperative transesophageal study”, Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography, vol. 24, n. 4, pp. 405-413, 2011.
- N.A. Marsan, F. Maffessanti, G. Tamborini, P. Gripari, E.G. Caiani, L. Fusini, M. Muratori, M. Zanobini, F. Alamanni, M. Pepi: “Left atrial reverse remodeling and functional improvement after mitral valve repair in degenerative mitral regurgitation: a real-time three-dimensional echocardiography study”, American heart journal, vol. 161, n. 2, pp. 314-321, 2011.
- F. Maffessanti, E.G. Caiani, G. Tamborini, M. Muratori, L. Sugeng, L. Weinert, F. Alamanni, M. Zanobini, V. Mor-Avi, RM. Lang, M. Pepi: “Serial Changes in Left Ventricular Shape Following Early Mitral Valve Repair”, The American journal of cardiology, vol. 106, n. 6, pp. 836-842, 2010.
- G. Tamborini, M. Muratori, A. Maltagliati, C.A. Galli, M. Naliato, M. Zanobini, F. Alamanni, L. Salvi, E. Sisillo, C. Fiorentini, M. Pepi: “Preoperative transthoracic real time three-dimensional echocardiography in patients undergoing mitral valve repair: accuracy in cases with simple vs complex prolapse lesions”, European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology, vol. 11, n. 9, pp. 778, 785, 2010.
- F. Maffessanti, R.M. Lang, C. Corsi, V. MorAvi, E.G. Caiani: “Feasibility of left ventricular shape analysis from transthoracic realtime 3D echocardiographic images”, Ultrasound in medicine & biology, vol. 35, pp. 1953-1962, 2009.
- G. Tamborini, M. Muratori, M. Celeste, F. Maffessanti, E.G. Caiani, F. Alamanni, M. Pepi: “Is right ventricular systolic function reduced after cardiac surgery? A two and three-dimensional echocardiographic study”, European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology, vol. 10, n. 5, pp. 630-634, 2009.
- F. Veronesi, C. Corsi, L. Sugeng, V. Mor-Avi, E.G. Caiani, L. Weinert, C. Lamberti, RM. Lang: “A study of functional anatomy of aortic-mitral valve coupling using 3D matrix transesophageal echocardiography”, Circulation. Cardiovascular imaging, vol. 2, pp. 24-31, 2009.
- E. Votta, E. Caiani, F. Veronesi, M. Soncini, F.M. Montevecchi, A. Redaelli: “Mitral valve finite-element modelling from ultrasound data: a pilot study for a new approach to understand mitral function and clinical scenarios”, Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, vol. 366, pp. 3411-3434, 2008.
